Biological half-life

The biological half-life or elimination half-life of a substance is the time it takes for a substance (for example a metabolite, drug, signalling molecule, radioactive nuclide, or other substance) to lose half of its pharmacologic, physiologic, or radiologic activity, as per the MeSH definition. In a medical context, half-life may also describe the time it takes for the blood plasma concentration of a substance to halve ("plasma half-life") its steady-state. The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues, active metabolites, and receptor interactions.[1]

Biological half-life is an important pharmacokinetic parameter and is usually denoted by the abbreviation t½.[2]

While a radioactive isotope decays perfectly according to first order kinetics where the rate constant is fixed, the elimination of a substance from a living organism, into the environment, follows more complex kinetics. See the article rate equation.

Contents

Examples of biological half-lives

Water

The biological half-life of water in a human is about 7 to 14 days. It can be altered by behavior. Drinking large amounts of alcohol will reduce the biological half-life of water in the body[3][4]. This has been used to decontaminate humans who are internally contaminated with tritiated water (tritium). Drinking the same amount of water would have a similar effect, but many would find it difficult to drink a large volume of water. The basis of this decontamination method (used at Harwell) is to increase the rate at which the water in the body is replaced with new water.

Alcohol

The removal of ethanol (drinking alcohol) through oxidation by alcohol dehydrogenase in the liver from the human body is limited. Hence the removal of a large concentration of alcohol from blood may follow zero-order kinetics. Also the rate-limiting steps for one substance may be in common with other substances. For instance, the blood alcohol concentration can be used to modify the biochemistry of methanol and ethylene glycol. In this way the oxidation of methanol to the toxic formaldehyde and formic acid in the (human body) can be prevented by giving an appropriate amount of ethanol to a person who has ingested methanol. Note that methanol is very toxic and causes blindness and death. A person who has ingested ethylene glycol can be treated in the same way.

Prescription medications

Substance Half-life
Adenosine < 10 seconds
Norepinephrine 2 minutes
Oxaliplatin 14 minutes[5]
Salbutamol 1.6 hours
Morphine 2 to 3 hours
Methadone 15 hours to 3 days, in rare cases up to 8 days.[6]
Fluoxetine 4 to 6 days*
Dutasteride 5 weeks

Metals

The biological half-life of caesium in humans is between one and four months. This can be shortened by feeding the person prussian blue. The prussian blue in the digestive system acts as a solid ion exchanger which absorbs the caesium while releasing potassium ions.

For some substances, it is important to think of the human or animal body as being made up of several parts, each with their own affinity for the substance, and each part with a different biological half-life (physiologically-based pharmacokinetic modelling). Attempts to remove a substance from the whole organism may have the effect of increasing the burden present in one part of the organism. For instance, if a person who is contaminated with lead is given EDTA in a chelation therapy, then while the rate at which lead is lost from the body will be increased, the lead within the body tends to relocate into the brain where it can do the most harm.

Rate equations

First-order elimination

There are circumstances where the half-life varies with the concentration of the drug. Thus the half-life, under these circumstances, is proportional to the initial concentration of the drug A0 and inversely proportional to the zero-order rate constant k0 where:

t_{1/2} = \frac{0.5 A_{0}}{k_{0}} \,

This process is usually a logarithmic process - that is, a constant proportion of the agent is eliminated per unit time.[7] Thus the fall in plasma concentration after the administration of a single dose is described by the following equation:

C = C_{0} e^{-Kt} \,

The relationship between the elimination rate constant and half-life is given by the following equation:

k = \frac{\ln 2}{t_{1/2}} \,

Half-life is determined by clearance (CL) and volume of distribution (VD) and the relationship is described by the following equation:

t_{1/2} = \frac{{\ln 2}\cdot{V_D}}{CL} \,

In clinical practice, this means that it takes 4 to 5 times the half-life for a drug's serum concentration to reach steady state after regular dosing is started, stopped, or the dose changed. So, for example, digoxin has a half-life (or t½) of 24–36 h; this means that a change in the dose will take the best part of a week to take full effect. For this reason, drugs with a long half-life (e.g. amiodarone, elimination t½ of about 58 days) are usually started with a loading dose to achieve their desired clinical effect more quickly.

Sample values and equations

Characteristic Description Example value Abbreviation(s) Formula
Dose Loading dose (LD), or steady state / maintenance dose (MD). 500 mg \textstyle D design parameter
τ Dosing interval. 24 h \textstyle \tau design parameter
Volume of distribution The apparent volume in which a drug is distributed immediately after it has been injected intravenously and equilibrated between plasma and the surrounding tissues. 6.0 L \textstyle V_d \textstyle = D / C_0
Concentration Initial or steady-state concentration of drug in plasma. 83.3 µg/mL \textstyle C_{0} \ or \ C_{ss} \textstyle = D / V_d
Biological half-life The time required for the concentration of the drug to reach half of its original value. 12 h \textstyle t_{1/2} \textstyle = ln (2) / k_{e}
Elimination rate constant The rate at which drugs are removed from the body. 0.0578 h-1 \textstyle k_e \textstyle = ln (2) / t_{1/2} = CL / V_{d}
Elimination rate Rate of infusion required to balance elimination. 50 mg/h \textstyle k_{in} \textstyle = C_{ss} \cdot CL
Area under the curve The integral of the concentration-time curve (after a single dose or in steady state). 1320 µg/mL×h \textstyle AUC_{0-\infty}

\textstyle AUC_{\tau,ss}		 = \int_{0}^{\infty}C\, dt
= \int_{t}^{t%2B\tau}C\, dt
Clearance The volume of plasma cleared of the drug per unit time. 0.38 L/h \textstyle CL \textstyle= V_{d} \cdot k_{e} = D/AUC
Bioavailability The fraction of drug that is absorbed. 0.8 \textstyle f = \frac{AUC_{po}\cdot D_{iv}}{AUC_{iv}\cdot D_{po}}
Cmax The peak plasma concentration of a drug after oral administration. 60.9 µg/mL \textstyle C_{max} direct measurement
tmax Time to reach Cmax. 3.9 h \textstyle t_{max} direct measurement
Cmin The lowest (trough) concentration that a drug reaches before the next dose is administered. 27.7 µg/mL \textstyle C_{min,ss} direct measurement
Fluctuation Peak trough fluctuation within one dosing interval at steady state 41.8 % \textstyle�%PTF \textstyle =100 \cdot \frac{(C_{max,ss} - C_{min,ss})}{C_{av,ss}}
where
\textstyle C_{av,ss}=\frac{AUC_{\tau,ss}}{\tau}
edit

See also

References

  1. ^ Lin VW; Cardenas DD (2003). Spinal cord medicine. Demos Medical Publishing, LLC. p. 251. ISBN 1888799617. http://books.google.com/?id=3anl3G4No_oC&pg=PA251&lpg=PA251. 
  2. ^ IUPAC, Compendium of Chemical Terminology, 2nd ed. (the "Gold Book") (1997). Online corrected version:  (2006–) "biological half life".
  3. ^ Nordberg, Gunnar (2007). Handbook on the toxicology of metals. Amsterdam: Elsevier. pp. 119. ISBN 0-12-369413-2. 
  4. ^ Silk, Kenneth R.; Tyrer, Peter J. (2008). Cambridge textbook of effective treatments in psychiatry. Cambridge, UK: Cambridge University Press. pp. 295. ISBN 0-521-84228-X. 
  5. ^ Ehrsson, Hans et al. (Winter 2002). Pharmacokinetics of oxaliplatin in humans. Medical Oncology. http://journals.humanapress.com/index.php?option=com_opbookdetails&task=articledetails&category=humanajournals&article_code=MO:19:4:261. Retrieved 2007-03-28. 
  6. ^ Manfredonia, John (March 2005). "Prescribing Methadone for Pain Management in End-of-Life Care". JAOA—The Journal of the American Osteopathic Association 105 (3 supplement): 18S. http://www.jaoa.org/cgi/content/full/105/3_suppl/18S. Retrieved 2007-01-29. 
  7. ^ Birkett DJ (2002). For example, ethanol may be consumed in sufficient quantity to saturate the metabolic enzymes in the liver, and so is eliminated from the body at an approximately constant rate (zero-order eliminationPharmacokinetics Made Easy (Revised Edition). Sydney: McGraw-Hill Australia. ISBN 0-07-471072-9.
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